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Polymorphism in the pharmaceutical industry by Rolf Hilfiker

Polymorphism in the pharmaceutical industry Rolf Hilfiker ebook
Publisher: Wiley-VCH
Format: pdf
Page: 433
ISBN: 3527311467, 9783527311460

"PhRMA is very disappointed with the Indian Supreme Court's decision to deny a patent on It's not sexy, but the guts of the decision came down to something called crystalline polymorphism--a fairly common phenomenon with solid chemicals. "The polymorph issue is so important to the pharmaceutical industry," Jerry Atwood of the University of Missouri-Columbia, told Science Service. On the other side of the opinion aisle, PhRMA, the trade association for the pharmaceutical industry, contributed its own hysteria. Labels: anthony crasto, DRUGS, medicinal chemistry, organic chemistry, POLYMORPHISM INDUSTRY. To overcome these challenges, the pharmaceutical industry is urgently searching for 2 solutions: “validated” gene targets and biomarkers that predict cardiovascular outcomes in a clinical trial (1,2). Take any tiny hint that someone with a certain polymorphism responds badly to a particular drug, and industry will claim the gene is bad, not the drug. Polymorphism and Crystallisation in Modern Pharmaceuticals by Pharma IQ - Polymorphism and crystallisation are among the most important and challenging areas of pharmaceuticals today, with new polymorph discoveries harbouring the potential to dramatically change the prop. Krishnan has developed analytical methods using X-ray diffraction for several polymorphic substances sponsored by pharmaceutical companies. Now, we are focusing on polymorphism and pseudo polymorphism, which is not only an academic challenge, but has great relevance for the pharmaceutical industry. What are some of the applications of crystal engineering?